|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1989-1-3
|
|
pubmed:abstractText |
A genetically homogeneous population of Plasmodium falciparum prepared by a single erythrocyte micromanipulation technique was used to produce lines of P. falciparum resistant to mefloquine hydrochloride in vitro. Parasites were maintained in a culture medium containing gradually increased concentrations of mefloquine hydrochloride (CMP-mef) starting with 2 ng/ml. One of the mefloquine-resistant culture lines (W2-mef) was obtained after 96 weeks of continuous culture in CMP-mef, the last 4 weeks in medium containing 40 ng/ml of mefloquine hydrochloride. The W2-mef was four to six times more resistant to mefloquine than was the parent clone W2. Means of multiple determinations of 50% inhibitory concentrations (IC-50) of mefloquine hydrochloride against W2-mef and clone W2 were 20.39 +/- 5.08 ng/ml and 4.50 +/- 1.94 ng/ml, respectively.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antimalarials,
http://linkedlifedata.com/resource/pubmed/chemical/Butylated Hydroxytoluene,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Mefloquine,
http://linkedlifedata.com/resource/pubmed/chemical/Phenanthrenes,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Quinolines,
http://linkedlifedata.com/resource/pubmed/chemical/WR 172435,
http://linkedlifedata.com/resource/pubmed/chemical/WR 184806,
http://linkedlifedata.com/resource/pubmed/chemical/WR 194965,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-(2-piperidyl)-3,6-bis(trifluor...,
http://linkedlifedata.com/resource/pubmed/chemical/enpiroline,
http://linkedlifedata.com/resource/pubmed/chemical/halofantrine
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0014-4894
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
67
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
354-60
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:3056740-Animals,
pubmed-meshheading:3056740-Antimalarials,
pubmed-meshheading:3056740-Butylated Hydroxytoluene,
pubmed-meshheading:3056740-Chemical Phenomena,
pubmed-meshheading:3056740-Chemistry,
pubmed-meshheading:3056740-Culture Media,
pubmed-meshheading:3056740-Drug Resistance,
pubmed-meshheading:3056740-Isoenzymes,
pubmed-meshheading:3056740-Mefloquine,
pubmed-meshheading:3056740-Phenanthrenes,
pubmed-meshheading:3056740-Plasmodium falciparum,
pubmed-meshheading:3056740-Pyridines,
pubmed-meshheading:3056740-Quinolines
|
|
pubmed:year |
1988
|
|
pubmed:articleTitle |
Plasmodium falciparum: induction of resistance to mefloquine in cloned strains by continuous drug exposure in vitro.
|
|
pubmed:affiliation |
Department of Parasitology and Laboratory Practice, School of Public Health, University of North Carolina, Chapel Hill 27514.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
