|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1987-8-27
|
|
pubmed:abstractText |
A surgically removed human stomach cancer with the histological diagnosis of poorly differentiated adenocarcinoma contained an activated N-ras oncogene detected by an in vivo selection assay in nude mice using transfected NIH3T3 cells. Analysis using synthetic 20-mer oligonucleotide probes revealed a point mutation from G to C at the first letter of codon 13 of the N-ras gene resulting in the substitution of arginine for glycine. This is the first observation of an activated N-ras oncogene in human stomach cancers.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0006-291X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
146
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
247-52
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:3038106-Adenocarcinoma,
pubmed-meshheading:3038106-Chromosomes, Human, Pair 13,
pubmed-meshheading:3038106-Codon,
pubmed-meshheading:3038106-Cytidine,
pubmed-meshheading:3038106-DNA Restriction Enzymes,
pubmed-meshheading:3038106-Guanine,
pubmed-meshheading:3038106-Humans,
pubmed-meshheading:3038106-Mutation,
pubmed-meshheading:3038106-Oncogenes,
pubmed-meshheading:3038106-RNA, Messenger,
pubmed-meshheading:3038106-Stomach Neoplasms
|
|
pubmed:year |
1987
|
|
pubmed:articleTitle |
A point mutation at codon 13 of the N-ras oncogene in a human stomach cancer.
|
|
pubmed:publicationType |
Journal Article
|
