| pubmed-article:3037230 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3037230 | lifeskim:mentions | umls-concept:C1882561 | lld:lifeskim |
| pubmed-article:3037230 | lifeskim:mentions | umls-concept:C0018328 | lld:lifeskim |
| pubmed-article:3037230 | lifeskim:mentions | umls-concept:C1155435 | lld:lifeskim |
| pubmed-article:3037230 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:3037230 | lifeskim:mentions | umls-concept:C0360641 | lld:lifeskim |
| pubmed-article:3037230 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:3037230 | pubmed:dateCreated | 1987-8-20 | lld:pubmed |
| pubmed-article:3037230 | pubmed:abstractText | Rat aortic smooth muscle homogenates and membrane preparations contain a phospholipase C which hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2). We discovered that guanyl-5'yl-imidodiphosphate (Gpp(NH)p) activated the hydrolysis of exogenous PIP2 but not of phosphatidylinositol (PI) in rat aortic membranes. Further, maximal Gpp(NH)p-dependent hydrolysis was dependent on physiological levels of calcium. Also, magnesium inhibited PIP2 hydrolysis and catalyzed the dephosphorylation of PIP2 to phosphatidylinositol-4-phosphate (PIP). The results imply that PIP2 is the primary substrate of the nucleotide-regulated phospholipase C in rat aorta and that calcium and magnesium are physiological regulators of this activity. | lld:pubmed |
| pubmed-article:3037230 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3037230 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3037230 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3037230 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3037230 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3037230 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3037230 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3037230 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3037230 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3037230 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3037230 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3037230 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3037230 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:3037230 | pubmed:issn | 0024-3205 | lld:pubmed |
| pubmed-article:3037230 | pubmed:author | pubmed-author:RothB LBL | lld:pubmed |
| pubmed-article:3037230 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3037230 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:3037230 | pubmed:volume | 41 | lld:pubmed |
| pubmed-article:3037230 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3037230 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3037230 | pubmed:pagination | 629-34 | lld:pubmed |
| pubmed-article:3037230 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:3037230 | pubmed:meshHeading | pubmed-meshheading:3037230-... | lld:pubmed |
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| pubmed-article:3037230 | pubmed:meshHeading | pubmed-meshheading:3037230-... | lld:pubmed |
| pubmed-article:3037230 | pubmed:meshHeading | pubmed-meshheading:3037230-... | lld:pubmed |
| pubmed-article:3037230 | pubmed:meshHeading | pubmed-meshheading:3037230-... | lld:pubmed |
| pubmed-article:3037230 | pubmed:meshHeading | pubmed-meshheading:3037230-... | lld:pubmed |
| pubmed-article:3037230 | pubmed:meshHeading | pubmed-meshheading:3037230-... | lld:pubmed |
| pubmed-article:3037230 | pubmed:meshHeading | pubmed-meshheading:3037230-... | lld:pubmed |
| pubmed-article:3037230 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3037230 | pubmed:articleTitle | Modulation of phosphatidylinositol-4,5-bisphosphate hydrolysis in rat aorta by guanine nucleotides, calcium and magnesium. | lld:pubmed |
| pubmed-article:3037230 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3037230 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3037230 | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3037230 | lld:pubmed |
