Linked Life Data

3036697

Source:http://linkedlifedata.com/resource/pubmed/id/3036697

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
77
pubmed:dateCreated
1987-7-28
pubmed:abstractText
Hexachlorobenzene (HCB) is hepatotoxic, causing a porphyria with an acquired deficiency of uroporphyrinogen decarboxylase. Conflicts have arisen regarding the toxicological significance of impurities in samples of HCB. In female rats, unpurified practical-grade HCB from Eastman Kodak Company was more porphyrogenic than a sample from Aldrich Chemical Company that had been recrystallized from benzene. To determine whether specific inducers of hepatic microsomal cytochrome P1-450, such as 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD), contributed to the difference in toxicity of these samples, induction of porphyria and activities of the cytochrome P1-450-dependent mono-oxygenase, ethoxyresorufin-O-deethylase (ERR), were compared in rats receiving HCB (0.2% w/w) or TCDD (10 micrograms/kg initial dose, then 2.5 micrograms/kg weekly). Porphyria occurred in the former but ERR activity was induced about four times more in the latter. The relative potency of crude and purified HCB samples in inducing ERR activity was further evaluated in C57Bl/6 and DBA/2 mice; ERR activity was three times higher in C57Bl/6 than in DBA/2 mice treated with 0.01% w/w HCB. ERR activity was also higher in C57Bl/6 mice treated with impure than in those treated with purified HCB. These results show that undefined impurities can be important determinants of the biological effects of HCB samples and suggest that these effects are partly mediated via the Ah receptor. However, porphyria induced by HCB appears to be independent of HCB impurities and not solely dependent on induction of the cytochrome-P1-450 mono-oxygenases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-5038
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
363-70
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
The role of contaminants in hexachlorobenzene toxicity.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't