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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1987-7-15
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pubmed:abstractText |
Infection of trigeminal ganglion by herpes simplex virus (HSV) thymidine kinase-negative (TK-) mutants was investigated in mixed infection studies in mice. Mice were corneally inoculated with TK- HSV alone or with mixtures of TK- HSV-TK+ HSV. When inoculated alone, an arabinosylthymine-selected HSV type 1 TK- mutant and a HSV type 2 TK- deletion mutant infected mouse ocular tissues but rarely infected ganglion tissues. However, both TK- mutants readily infected ganglion tissues when they were inoculated in mixtures with TK+ HSV. By means of mixed infection studies, it was demonstrated that TK- HSV could readily establish acute and latent ganglion infections. It was thought that the frequent infection of trigeminal ganglion tissue by both TK- mutants after mixed TK(-)-TK+ HSV infection was the result of in vivo complementation. After mixed TK(-)-TK+ HSV infection and subsequent cultivation of ganglion explants in arabinosylthymine, results supported the conclusion that when TK- was present in ganglia it was in the same neurons that contained TK+ HSV.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3035217-167520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3035217-197264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3035217-212476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3035217-229629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3035217-2982968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3035217-2991439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3035217-2991558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3035217-2991566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3035217-3022474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3035217-4372299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3035217-6088797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3035217-6090708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3035217-6247969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3035217-6251784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3035217-6264689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3035217-6273321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3035217-6298344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3035217-6305312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3035217-6307880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3035217-6315865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3035217-6826696
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2171-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3035217-Animals,
pubmed-meshheading:3035217-Female,
pubmed-meshheading:3035217-Genetic Complementation Test,
pubmed-meshheading:3035217-Keratitis, Dendritic,
pubmed-meshheading:3035217-Male,
pubmed-meshheading:3035217-Mice,
pubmed-meshheading:3035217-Simplexvirus,
pubmed-meshheading:3035217-Thymidine Kinase,
pubmed-meshheading:3035217-Trigeminal Ganglion,
pubmed-meshheading:3035217-Trigeminal Nerve,
pubmed-meshheading:3035217-Viral Proteins,
pubmed-meshheading:3035217-Virus Cultivation
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pubmed:year |
1987
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pubmed:articleTitle |
Trigeminal ganglion infection by thymidine kinase-negative mutants of herpes simplex virus after in vivo complementation.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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