Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1987-6-5
|
| pubmed:abstractText |
The authors examined paraffin sections from 85 genital tract tissues from 49 cases for the presence of human papillomavirus (HPV) Types 6/11, 16, and 18 by stringent in situ hybridization using 35S-labeled viral DNA probes, and for viral capsid antigen by the immunoperoxidase test. The cases, selected mostly on the basis of vulvar pathology, were distributed as follows: early neoplasia (Group I, 6 cases); early neoplasia with viral cytopathic effect (CE) (Group II, 24 cases); and papillomavirus infection (PVI) (Group III, 19 cases). Available tissues from all affected sites were examined when the disease was multicentric. One or more viral DNAs were identified in 58% of 77 tissues from Groups II and III and in 2 of 8 tissues from Group I. HPV-6/11, HPV-16 and HPV-18 DNAs were detected, respectively, in 25, 24, and 2 tissues; 3 tissues were infected simultaneously with either two or three viruses. Viral DNA was identified at more than one site in 14 of 30 DNA-positive patients; in 10 of these, a single type was detected at all sites in the same patient. The viral DNA was localized mostly in areas showing viral cytopathology. The presence of HPV-16 correlated with neoplasia. HPV-16 DNA was identified in the 2 virus-positive tissues showing neoplasia, in 17 of 20 (85%) of the DNA-positive tissues showing neoplasia with CE, and in 5 of 25 (20%) of the DNA-positive tissues showing PVI. Conversely, HPV-6/11 was found in 25% of the DNA-positive tissues showing neoplasia with CE and in 80% of the cases of PVI. An HPV genome was identified in neoplastic cells in 14 instances; in all but 1 case, the genome was HPV-16. The association of HPV-16 with neoplasia was seen for both vulvar and cervical lesions. Viral antigen was detected in 83% of lesions associated with HPV 6/11 and in 62% of lesions associated with HPV-16.
|
| pubmed:grant | |
| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3034064-216014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3034064-2421580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3034064-2987521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3034064-2993496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3034064-2997054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3034064-3004312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3034064-3025074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3034064-4583016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3034064-6093610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3034064-6095166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3034064-6277449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3034064-6281161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3034064-6285742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3034064-6287842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3034064-6292500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3034064-6300854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3034064-6313535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3034064-6321986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3034064-6329740
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0002-9440
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
127
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
206-15
|
| pubmed:dateRevised |
2009-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:3034064-Adult,
pubmed-meshheading:3034064-Aged,
pubmed-meshheading:3034064-Antigens, Viral,
pubmed-meshheading:3034064-DNA, Viral,
pubmed-meshheading:3034064-Female,
pubmed-meshheading:3034064-Genital Neoplasms, Female,
pubmed-meshheading:3034064-Humans,
pubmed-meshheading:3034064-Middle Aged,
pubmed-meshheading:3034064-Nucleic Acid Hybridization,
pubmed-meshheading:3034064-Papillomaviridae,
pubmed-meshheading:3034064-Vulvar Neoplasms
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Association of human papillomavirus type 16 with neoplastic lesions of the vulva and other genital sites by in situ hybridization.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|