Linked Life Data

3033173

Source:http://linkedlifedata.com/resource/pubmed/id/3033173

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1987-5-22
pubmed:abstractText
We investigated [201Tl]diethyldithiocarbamate (DDC) as a tracer for local cerebral blood flow (LCBF). Awake male rats were given intravenous infusions of a mixture of DDC and reference tracer(s): [123I]isopropyliodoamphetamine (IMP) and/or [14C]iodoantipyrine (IAP). LCBF values for DDC, IMP, and IAP were measured using simultaneous multiple radionuclide autoradiography and quantitative digital image analysis. Patterns of local cerebral blood flow (LCBF) obtained with DDC were intermediate compared to IMP and IAP, although they were more similar to those of IMP. DDC and IMP underestimated LCBF in some white matter and adjacent structures, while IAP underestimated LCBF values in high flow regions. We conclude that DDC uptake generally reflects local cerebral blood flow and that it can therefore be used as a cerebral perfusion tracer in humans using SPECT imaging.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0161-5505
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
481-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Autoradiographic comparison of thallium-201 diethyldithiocarbamate, isopropyliodoamphetamine and iodoantipyrine as cerebral blood flow tracers.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.