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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1987-4-13
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pubmed:abstractText |
The ability to mount an immune response to simian virus 40 (SV40) T antigen was evaluated using mice from two distinct SV40 transgenic lines derived from injection of the same gene construct. Our studies demonstrate functional immune tolerance to SV40 T antigen in a SV40 transgenic line that consistently develops tumors of the choroid plexus by 7 mo of age. Antibodies to SV40 T antigen are undetectable in the serum of these animals; furthermore, mice from this line are unable to generate SV40-specific CTL after primary or secondary immunization with the virus, although they mount a normal CTL response to vaccinia virus when appropriately immunized. In contrast, we find that mice from a second transgenic line of low tumor incidence can mount a humoral response to SV40 T antigen, and upon immunization they generally respond with a vigorous cytotoxic T cell response to SV40 T antigen. These data suggest that specific immune tolerance to the product of an integrated viral oncogene may be induced, and is likely a reflection of the time in development at which the gene product first appears. Immune tolerance or responsiveness to the endogenous oncogene product may in turn play a role in the tumorigenic potential of such genes.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3029269-13099277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3029269-191529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3029269-194983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3029269-2986015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3029269-2991771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3029269-3007009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3029269-323401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3029269-3865369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3029269-4125922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3029269-4371155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3029269-6087163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3029269-6187124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3029269-6212255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3029269-6229792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3029269-6286762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3029269-6319753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3029269-6409417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3029269-6409418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3029269-6455666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3029269-6460693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3029269-7016992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3029269-87443
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
165
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
417-27
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3029269-Animals,
pubmed-meshheading:3029269-Antibodies, Viral,
pubmed-meshheading:3029269-Antigens, Polyomavirus Transforming,
pubmed-meshheading:3029269-Antigens, Viral, Tumor,
pubmed-meshheading:3029269-Cell Transformation, Neoplastic,
pubmed-meshheading:3029269-Cell Transformation, Viral,
pubmed-meshheading:3029269-Immune Tolerance,
pubmed-meshheading:3029269-Immunization,
pubmed-meshheading:3029269-Mice,
pubmed-meshheading:3029269-Mice, Inbred C57BL,
pubmed-meshheading:3029269-Neoplasms, Experimental,
pubmed-meshheading:3029269-Oncogene Proteins, Viral,
pubmed-meshheading:3029269-Recombination, Genetic,
pubmed-meshheading:3029269-Simian virus 40,
pubmed-meshheading:3029269-T-Lymphocytes, Cytotoxic
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pubmed:year |
1987
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pubmed:articleTitle |
Simian virus 40 (SV40)-transgenic mice that develop tumors are specifically tolerant to SV40 T antigen.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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