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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1987-4-9
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pubmed:abstractText |
Long-term (14 days) treatment of mice with the antidepressant drug imipramine increased the number of GABA-B receptors in the cerebral cortex and also led to an increase in the potentiation of norepinephrine-induced cAMP accumulation by baclofen (a GABA-B agonist) in cortical slices. Chronic baclofen treatment decreased both of these measures. These results suggest that previous evidence of increased GABA-B binding by antidepressants is coupled to a functional increase in adenylate cyclase activity, but that the mechanism responsible for this effect is not due simply to direct GABA-B receptor stimulation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-2999
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
129-33
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3028823-Animals,
pubmed-meshheading:3028823-Baclofen,
pubmed-meshheading:3028823-Cerebral Cortex,
pubmed-meshheading:3028823-Cyclic AMP,
pubmed-meshheading:3028823-Imipramine,
pubmed-meshheading:3028823-Male,
pubmed-meshheading:3028823-Mice,
pubmed-meshheading:3028823-Norepinephrine,
pubmed-meshheading:3028823-Receptors, GABA-A,
pubmed-meshheading:3028823-gamma-Aminobutyric Acid
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pubmed:year |
1986
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pubmed:articleTitle |
Effect of chronic imipramine or baclofen on GABA-B binding and cyclic AMP production in cerebral cortex.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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