Linked Life Data

3022554

Source:http://linkedlifedata.com/resource/pubmed/id/3022554

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-12-5
pubmed:abstractText
In the last few years, quantitative receptor autoradiography has been extensively employed to study the distribution and the functional role of area-specific transmitter receptors in the central nervous system. In the present paper we have developed quantitative methodologies for the analysis of autoradiograms using computerized image analysers coupled with standard TV camera input for the microdensitometrical evaluations. These procedures include the assessment of the film response to radioactivity using appropriate standards calibrated according to brain tissue quenching and non-linear conversion of density measurements in radioactivity values adopting the best mathematical model fitting to give as little variability as possible in the transformations. The reliability of the proposed approach has also been evaluated by means of a computer-assisted Monte Carlo simulation and parallel biochemical determinations.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0001-6772
pubmed:author
pubmed:issnType
Print
pubmed:volume
128
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
129-46
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Quantitative autoradiography of central neurotransmitter receptors: methodological and statistical aspects with special reference to computer-assisted image analysis.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't