Linked Life Data

3021486

Source:http://linkedlifedata.com/resource/pubmed/id/3021486

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1986-12-18
pubmed:abstractText
Nedocromil sodium is the disodium salt of a novel pyranoquinoline dicarboxylic acid which has physicochemical and pharmacokinetic properties which make it suitable for delivery to the respiratory tract by inhalation. Its biological properties suggest that it will display anti-allergic effects in man and that it will also have anti-inflammatory activity in chronic reversible obstructive airways disease. The clinical development of nedocromil sodium has been influenced by its anticipated effects in man and also by the knowledge that preclinical and early clinical tests are poor predictors of efficacy for agents of this type. Thus, although nedocromil sodium prevents immediate and delayed reactions to bronchial antigen challenge, and also prevents exercise-induced bronchoconstriction, the clinical development programme of this drug was designed to provide therapeutic double-blind trials of 1 month's treatment with the drug at the earliest opportunity, because this was thought to be the definitive test for activity. Studies on a larger scale and of longer duration followed the positive outcome of the first therapeutic trials. This series of studies, conducted to different designs, demonstrated the safety and efficacy of nedocromil sodium. They also permitted a view to be gained of the place of nedocromil sodium in the management of patients with airways inflammation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0106-4347
pubmed:author
pubmed:issnType
Print
pubmed:volume
147
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
120-31
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
The clinical development of a new agent for the treatment of airway inflammation, nedocromil sodium (Tilade).
pubmed:publicationType
Journal Article, In Vitro