| pubmed-article:3014157 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3014157 | lifeskim:mentions | umls-concept:C0013935 | lld:lifeskim |
| pubmed-article:3014157 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:3014157 | lifeskim:mentions | umls-concept:C0034785 | lld:lifeskim |
| pubmed-article:3014157 | lifeskim:mentions | umls-concept:C0599283 | lld:lifeskim |
| pubmed-article:3014157 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:3014157 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:3014157 | pubmed:dateCreated | 1986-7-28 | lld:pubmed |
| pubmed-article:3014157 | pubmed:abstractText | Factors which regulate beta-adrenergic receptor density in non-innervated and denervated embryonic tissues have not been fully elucidated. In the present study, the effects of exposure to isoproterenol and propranolol on beta-adrenergic receptor density in the non-innervated (preneural) and partially innervated (neural) embryonic chick heart are examined. In addition, the effects of chemical and surgical sympathectomy on cardiac beta-adrenergic receptor density in the chick embryo are investigated. (125I)-pindolol was used as a receptor probe. The density of beta-adrenergic receptors in the embryonic chick heart peaks on incubation day 9 (664 fmols/mg protein) and then decreases by more than 80% by incubation day 19. Administration of propranolol or isoproterenol on incubation days 4 to 6 results in no change or a decrease (to 62% of control), respectively, in receptor density on incubation day 7. Administration of propranolol on incubation days 10 to 19 causes an increase (to 230% of control) in beta-adrenergic receptor density on day 20. Administration of isoproterenol on incubation days 10 to 16 results in a decrease (to 26% of control) in receptor density on day 17. Neither chemical sympathectomy, produced by administration of 6-hydroxydopamine, nor surgical sympathectomy, produced by removal of premigratory neural crest cells, significantly alters cardiac beta-adrenergic receptor density from control values. Administration of adrenergic drugs produces a greater change in beta-adrenergic receptor density after sympathetic innervation (day 10) than in preneural hearts. This indicates that sympathetic nerves influence the properties of beta-adrenergic receptors during embryonic development. | lld:pubmed |
| pubmed-article:3014157 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3014157 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3014157 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3014157 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3014157 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3014157 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3014157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3014157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3014157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3014157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3014157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3014157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3014157 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3014157 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3014157 | pubmed:month | May | lld:pubmed |
| pubmed-article:3014157 | pubmed:issn | 0022-2828 | lld:pubmed |
| pubmed-article:3014157 | pubmed:author | pubmed-author:AronstamR SRS | lld:pubmed |
| pubmed-article:3014157 | pubmed:author | pubmed-author:KirbyM LML | lld:pubmed |
| pubmed-article:3014157 | pubmed:author | pubmed-author:StewartD EDE | lld:pubmed |
| pubmed-article:3014157 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3014157 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:3014157 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3014157 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3014157 | pubmed:pagination | 469-75 | lld:pubmed |
| pubmed-article:3014157 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3014157 | pubmed:meshHeading | pubmed-meshheading:3014157-... | lld:pubmed |
| pubmed-article:3014157 | pubmed:meshHeading | pubmed-meshheading:3014157-... | lld:pubmed |
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| pubmed-article:3014157 | pubmed:meshHeading | pubmed-meshheading:3014157-... | lld:pubmed |
| pubmed-article:3014157 | pubmed:meshHeading | pubmed-meshheading:3014157-... | lld:pubmed |
| pubmed-article:3014157 | pubmed:meshHeading | pubmed-meshheading:3014157-... | lld:pubmed |
| pubmed-article:3014157 | pubmed:meshHeading | pubmed-meshheading:3014157-... | lld:pubmed |
| pubmed-article:3014157 | pubmed:meshHeading | pubmed-meshheading:3014157-... | lld:pubmed |
| pubmed-article:3014157 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3014157 | pubmed:articleTitle | Regulation of beta-adrenergic receptor density in the non-innervated and denervated embryonic chick heart. | lld:pubmed |
| pubmed-article:3014157 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3014157 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:3014157 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3014157 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
