Linked Life Data

3014157

Source:http://linkedlifedata.com/resource/pubmed/id/3014157

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1986-7-28
pubmed:abstractText
Factors which regulate beta-adrenergic receptor density in non-innervated and denervated embryonic tissues have not been fully elucidated. In the present study, the effects of exposure to isoproterenol and propranolol on beta-adrenergic receptor density in the non-innervated (preneural) and partially innervated (neural) embryonic chick heart are examined. In addition, the effects of chemical and surgical sympathectomy on cardiac beta-adrenergic receptor density in the chick embryo are investigated. (125I)-pindolol was used as a receptor probe. The density of beta-adrenergic receptors in the embryonic chick heart peaks on incubation day 9 (664 fmols/mg protein) and then decreases by more than 80% by incubation day 19. Administration of propranolol or isoproterenol on incubation days 4 to 6 results in no change or a decrease (to 62% of control), respectively, in receptor density on incubation day 7. Administration of propranolol on incubation days 10 to 19 causes an increase (to 230% of control) in beta-adrenergic receptor density on day 20. Administration of isoproterenol on incubation days 10 to 16 results in a decrease (to 26% of control) in receptor density on day 17. Neither chemical sympathectomy, produced by administration of 6-hydroxydopamine, nor surgical sympathectomy, produced by removal of premigratory neural crest cells, significantly alters cardiac beta-adrenergic receptor density from control values. Administration of adrenergic drugs produces a greater change in beta-adrenergic receptor density after sympathetic innervation (day 10) than in preneural hearts. This indicates that sympathetic nerves influence the properties of beta-adrenergic receptors during embryonic development.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-2828
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
469-75
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Regulation of beta-adrenergic receptor density in the non-innervated and denervated embryonic chick heart.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't