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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1986-6-23
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pubmed:abstractText |
We report a molecular analysis of the chicken Ig loci in single bursal follicles from 3- to 7-week-old chickens. Each follicle contained between 10(5) and 3 X 10(5) cells. The Ig gene rearrangement patterns obtained were compared to the pattern observed with the corresponding total bursal DNA. The results obtained for the light chain locus imply that a very small number (two on average) of rearrangement events takes place in each follicle. For the heavy chain locus similar results were obtained, each follicle showing a more restricted pattern than the total bursa. These data favor a model in which each follicle is colonized by a very few prebursal stem cells that are committed to a particular Ig gene rearrangement at the very beginning of the development of the embryonic bursa. The role of the bursa as the organ in which such a committed stem cell population for the B-cell lineage arises is discussed.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-1101262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-140917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-291033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-3485527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-3871398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-3874075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-3874257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-3875650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-3903518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-39107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-3917859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-3924409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-3930970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-4016956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-4203295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-5636553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-6086308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-6264446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-6310496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-6334312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-6408641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-6454581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-6607968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-6783959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-6966820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-6969781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-7106862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-724605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-881736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3010290-992209
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3336-40
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3010290-Animals,
pubmed-meshheading:3010290-B-Lymphocytes,
pubmed-meshheading:3010290-Bursa of Fabricius,
pubmed-meshheading:3010290-Chick Embryo,
pubmed-meshheading:3010290-Cyclophosphamide,
pubmed-meshheading:3010290-DNA Restriction Enzymes,
pubmed-meshheading:3010290-Heterozygote,
pubmed-meshheading:3010290-Immunoglobulin Constant Regions,
pubmed-meshheading:3010290-Immunoglobulin Heavy Chains,
pubmed-meshheading:3010290-Immunoglobulin Light Chains,
pubmed-meshheading:3010290-Immunoglobulin Variable Region,
pubmed-meshheading:3010290-Immunoglobulin lambda-Chains,
pubmed-meshheading:3010290-Immunoglobulin mu-Chains,
pubmed-meshheading:3010290-Polymorphism, Genetic,
pubmed-meshheading:3010290-Recombination, Genetic
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pubmed:year |
1986
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pubmed:articleTitle |
Rearrangement of chicken immunoglobulin genes is not an ongoing process in the embryonic bursa of Fabricius.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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