Linked Life Data

3010195

Source:http://linkedlifedata.com/resource/pubmed/id/3010195

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-6-9
pubmed:abstractText
In the isolated ileum of the guinea pig, neurally mediated rhythmic longitudinal mechanical activity was induced by avermectin, a macrolide anthelmintic that releases gamma-aminobutyric acid (GABA) and modulates the GABAA-receptor-ionophore complex. This avermectin-induced activity was dependent on GABA, being reduced or abolished by bicuculline, a GABAA-receptor antagonist, and by 3-mercaptopropionic acid which prevents neural GABA release. These results provide additional direct evidence that GABA is a functional neurotransmitter in the myenteric plexus of the guinea pig intestine, evidently involved in the regulation of intestinal motility.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7-10
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
gamma-Aminobutyric acid-dependent motility induced by avermectin B1a in the isolated intestine of the guinea pig.
pubmed:publicationType
Journal Article, In Vitro