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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1986-3-26
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pubmed:abstractText |
A molecular linkage analysis in 11 families with X-linked agammaglobulinemia (XLA) localized the XLA gene to the proximal part of the long arm of the human X chromosome. Significant linkage was detected between XLA and loci defined by two polymorphic DNA probes called 19-2 for the DXS3 locus and S21 for the DXS17 locus. Both localize to the region Xq21.3-Xq22. Most likely recombination distances (theta) and associated logarithm of the odds (lod) scores for the XLA-DXS3 and XLA-DXS17 pairs were theta = 0.04 morgans (lod, 3.65) and theta = 0 (lod, 2.17), respectively. Tight linkage between XLA and the locus DXS43 defined by the X short arm probe D2 (localized to Xp22-Xp21) was strongly excluded and we obtained no evidence for significant linkage between XLA and any other X short arm probe. The probe pair 19-2 and S21 should be informative for molecular linkage-based analysis of XLA segregation in the majority of families afflicted with this disorder.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-2581110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-265567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-2988331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-2994010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-346998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-4039107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-4578158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-474618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-6188151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-6224853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-6234467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-6247908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-6291041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-6304647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-6326147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-6328976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-6349887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-6372096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-6461845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-6482910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-6885061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-6982420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-6994459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003164-7307343
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
649-52
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3003164-Agammaglobulinemia,
pubmed-meshheading:3003164-Chromosome Mapping,
pubmed-meshheading:3003164-DNA,
pubmed-meshheading:3003164-DNA, Recombinant,
pubmed-meshheading:3003164-DNA Restriction Enzymes,
pubmed-meshheading:3003164-Humans,
pubmed-meshheading:3003164-Nucleic Acid Hybridization,
pubmed-meshheading:3003164-Polymorphism, Genetic,
pubmed-meshheading:3003164-Recombination, Genetic,
pubmed-meshheading:3003164-X Chromosome
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pubmed:year |
1986
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pubmed:articleTitle |
Mapping of the X-linked agammaglobulinemia locus by use of restriction fragment-length polymorphism.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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