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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1986-2-14
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pubmed:abstractText |
A Phase II Study of VP-16 was performed in 58 patients with primary lung cancer. VP-16 was administered via infusion at a dosage of 60-100 mg/m2 daily for 5 days, and repeated every 3 to 4 weeks. Of the 58 patients who entered into the study, 38 were evaluable. Partial response was observed in 6 patients who had been diagnosed as having small cell carcinoma of the lung. Response rates were 15.8% for all evaluated patients and 33.3% for the patients with small cell carcinoma of the lung. As for dose-limiting toxicity, leukopenia (less than 3,000/mm3) was observed in 53.1% of cases. Other major adverse reactions were hematologic toxicities such as anemia and thrombocytopenia, gastrointestinal toxicities and alopecia, but these were all well tolerated.
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pubmed:language |
jpn
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0385-0684
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
116-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3002282-Adenocarcinoma,
pubmed-meshheading:3002282-Adult,
pubmed-meshheading:3002282-Aged,
pubmed-meshheading:3002282-Alopecia,
pubmed-meshheading:3002282-Anorexia,
pubmed-meshheading:3002282-Carcinoma, Small Cell,
pubmed-meshheading:3002282-Carcinoma, Squamous Cell,
pubmed-meshheading:3002282-Drug Administration Schedule,
pubmed-meshheading:3002282-Drug Evaluation,
pubmed-meshheading:3002282-Etoposide,
pubmed-meshheading:3002282-Female,
pubmed-meshheading:3002282-Humans,
pubmed-meshheading:3002282-Injections,
pubmed-meshheading:3002282-Lung Neoplasms,
pubmed-meshheading:3002282-Male,
pubmed-meshheading:3002282-Middle Aged,
pubmed-meshheading:3002282-Nausea,
pubmed-meshheading:3002282-Podophyllotoxin
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pubmed:year |
1986
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pubmed:articleTitle |
[A phase II study of etoposide (VP-16) injection in primary lung cancer by cooperative study group].
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pubmed:publicationType |
Journal Article,
English Abstract
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