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pubmed:abstractText |
Examination of mammalian steroid hormones, their metabolites and semi-synthetic analogs in a radioreceptor binding assay for cardiac glycosides led to the identification of active derivatives of hydroxyprogesterone. The active compounds are potent inhibitors of purified sodium, potassium-ATPase and of the sodium pump in isolated tissues. Metabolism of progesterone offers a mechanism for the generation of endogenous substances that resemble, both structurally and biologically, the digitalis cardioactive steroids.
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