| pubmed-article:2996727 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2996727 | lifeskim:mentions | umls-concept:C0008377 | lld:lifeskim |
| pubmed-article:2996727 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2996727 | lifeskim:mentions | umls-concept:C0012155 | lld:lifeskim |
| pubmed-article:2996727 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:2996727 | lifeskim:mentions | umls-concept:C0001473 | lld:lifeskim |
| pubmed-article:2996727 | lifeskim:mentions | umls-concept:C0204695 | lld:lifeskim |
| pubmed-article:2996727 | lifeskim:mentions | umls-concept:C2266865 | lld:lifeskim |
| pubmed-article:2996727 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2996727 | pubmed:dateCreated | 1985-12-13 | lld:pubmed |
| pubmed-article:2996727 | pubmed:abstractText | ATPase and calcium binding activities were studied in sarcolemmal membranes from hearts of male rats fed either a control or 2% cholesterol diet for different time periods. Studies with isolated membrane revealed a significant increase in Na+-K+ ATPase activity, sialic acid content and ATP-independent calcium binding capacity in the presence of 1.25 mM CaCl2 in the 6 week cholesterol fed group. By 12 weeks, Na+-K+ ATPase, Mg2+-ATPase and Ca2+-ATPase activities as well as ATP-independent calcium binding in the presence of 0.05 mM CaCl2 were increased in membranes from cholesterol fed rats. A significant increase (P less than 0.05) in the sarcolemmal cholesterol/phospholipid molar ratio, which is an indicator of a decrease in membrane fluidity, was also noted in the 12 week cholesterol fed group. Concanavalin A, which is believed to decrease membrane fluidity, stimulated both Mg2+ and Ca2+-dependent ATPase activities and increased ATP-independent calcium binding in control sarcolemmal preparations and these changes resembled those observed in the sarcolemma from cholesterol fed rats. Since concanavalin A did not alter the activity of Na+-K+ ATPase, it appears that some of the observed differences in sarcolemmal activities upon cholesterol feeding did not correlate well with changes in membrane order. At 24 weeks, there was a generalized depression in the sarcolemmal ATPase activities of the cholesterol group; both Mg2+ ATPase and Ca2+ ATPase were significantly less than in control.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:2996727 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2996727 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2996727 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2996727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2996727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2996727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2996727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2996727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2996727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2996727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2996727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2996727 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2996727 | pubmed:issn | 0828-282X | lld:pubmed |
| pubmed-article:2996727 | pubmed:author | pubmed-author:DhallaN SNS | lld:pubmed |
| pubmed-article:2996727 | pubmed:author | pubmed-author:MoffatM PMP | lld:pubmed |
| pubmed-article:2996727 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2996727 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:2996727 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2996727 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2996727 | pubmed:pagination | 194-200 | lld:pubmed |
| pubmed-article:2996727 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:2996727 | pubmed:articleTitle | Heart sarcolemmal ATPase and calcium binding activities in rats fed a high cholesterol diet. | lld:pubmed |
| pubmed-article:2996727 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2996727 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
