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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1985-11-4
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pubmed:abstractText |
We investigated, in 36 healthy volunteers, the effects of prednisone and ketotifen on recovery of lymphocyte beta 2-adrenoceptor density (determined by (-)-125iodocyanopindolol binding) and responsiveness (assessed by lymphocyte cyclic AMP [cAMP] responses to 10 microM (-)-isoprenaline) after desensitization by the beta 2-agonist terbutaline. Terbutaline (3 X 5 mg/d) decreased lymphocyte beta 2-adrenoceptor density by approximately 40-50%; concomitantly, lymphocyte cAMP responses to 10 microM (-)-isoprenaline were significantly reduced. After withdrawal of terbutaline beta 2-adrenoceptor, density and responsiveness gradually increased, reaching predrug levels after 4 d. Prednisone (1 X 100 mg orally) accelerated beta 2-adrenoceptor recovery; only 8-10 h after administration of the steroid beta 2-adrenoceptor density and cAMP responses to (-)-isoprenaline had reached values not significantly different from pretreatment levels. Similar effects were obtained with ketotifen (2 mg; thereafter 2 X 1 mg/d for 4 d): 24 h after application of the drug beta 2-adrenoceptor density and cAMP responses to (-)-isoprenaline had reached pretreatment levels. Furthermore, ketotifen simultaneously applied with terbutaline completely prevented terbutaline-induced decrease in lymphocyte beta 2-adrenoceptor density and responsiveness. Prednisone (1 X 100 mg orally) or ketotifen (2 mg; thereafter 2 X 1 mg/d for 2 d) had no significant influence on lymphocyte beta 2-adrenoceptor density in healthy volunteers not pretreated with terbutaline, but shifted the ratio high-to-low affinity state of the lymphocyte beta 2-adrenoceptor toward high affinity state. We conclude that glucocorticoids as well as ketotifen can accelerate recovery of density and responsiveness of lymphocyte beta 2-adrenoceptors desensitized by long-term treatment with beta 2-agonists. Such an effect may have clinical implications for preventing tachyphylaxis of asthmatic patients against therapy with beta 2-agonists.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-186488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-192771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-203616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-207294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-216063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-223168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-29223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-335936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-4260799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-4318781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-4337859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-4341943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-4400573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-54795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-5789811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-5922985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-6095706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-6098662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-6101600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-6108126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-6116722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-6119625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-6123082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-6125416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-6129315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-6131826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-6138782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-6143332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-6243320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-6248556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-6251106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-6275222,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-6292641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-6298219,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-6311563,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-6324653,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-6777076,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2995446-7100055
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1096-101
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2995446-Adult,
pubmed-meshheading:2995446-Cyclic AMP,
pubmed-meshheading:2995446-Female,
pubmed-meshheading:2995446-Heart Rate,
pubmed-meshheading:2995446-Humans,
pubmed-meshheading:2995446-Iodocyanopindolol,
pubmed-meshheading:2995446-Isoproterenol,
pubmed-meshheading:2995446-Ketotifen,
pubmed-meshheading:2995446-Kinetics,
pubmed-meshheading:2995446-Lymphocytes,
pubmed-meshheading:2995446-Male,
pubmed-meshheading:2995446-Pindolol,
pubmed-meshheading:2995446-Prednisone,
pubmed-meshheading:2995446-Receptors, Adrenergic, beta,
pubmed-meshheading:2995446-Tachyphylaxis,
pubmed-meshheading:2995446-Terbutaline
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pubmed:year |
1985
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pubmed:articleTitle |
Terbutaline-induced desensitization of human lymphocyte beta 2-adrenoceptors. Accelerated restoration of beta-adrenoceptor responsiveness by prednisone and ketotifen.
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