Linked Life Data

2960576

Source:http://linkedlifedata.com/resource/pubmed/id/2960576

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-1-15
pubmed:abstractText
Bat spleen and mesenteric lymph node cell cultures treated with varying doses of LPS showed significant blastogenic and DNA synthetic responses between 72-96h. Peak responses were not different when the cell culture medium was supplemented either with autologous serum or heterologous serum indicating the absence of any significant suppressor factor in autologous bat serum. In contrast, blastogenesis and DNA synthesis peaks appeared early, at 48h, in lymphocytes depleted of suppressor T cells by pretreatment with cyclophosphamide. Direct antibody producing cells against SRBC were studied in normal spleen and mesenteric lymph node cell cultures. The peak PFC response was lacking even at 120h while CY pretreated bat lymphocytes, showed peak PFC responses at 96h. Thus the delayed immune response in bats seems to be a function of suppressor T cells but serum suppressor factor(s) possibly exerts no significant effect. The function of suppressor cells in bats in relation to their role as carriers of several dreaded bacteria and viruses is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0145-305X
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
649-60
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Analysis of suppressor factor in delayed immune responses of a bat, Pteropus giganteus.
pubmed:affiliation
Immunology and Cell Biology Lab., University of North Bengal, Dist. Darjeeling, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't