Linked Life Data

2949120

Source:http://linkedlifedata.com/resource/pubmed/id/2949120

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-3-12
pubmed:abstractText
Leukaemic cells from the peripheral blood of 90 patients with acute leukaemia (54 non-lymphocytic (ANLL) 36 lymphocytic (ALL)) have been examined for the presence of the platelet/ALL-associated p24 membrane antigen by indirect immunofluorescence and flow cytometry using monoclonal antibody FMC8. Cells from 28 of the ANLL patients and 24 of the ALL patients expressed the antigen. In many specimens, both ANLL and ALL, blast cell populations were heterogeneous with respect to FMC8 binding. In ANLL, FMC8-positive cells were observed in specimens from a range of morphological subtypes. Proteolytic stripping/resynthesis experiments demonstrated that the antigen was synthesized by ANLL cells, not passively acquired. Immunoprecipitation and electrophoretic analysis of the antigen from NP40 lysates of 125I surface labelled cells from a patient with acute monoblastic leukaemia confirmed that the epitope identified by FMC8 was present on a peptide of the same molecular weight (p24) as that observed on ALL cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0145-2126
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
97-101
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Expression of the non-T ALL-associated p24 antigen on leukaemic blasts from patients with ANLL.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't