Linked Life Data

2937138

Source:http://linkedlifedata.com/resource/pubmed/id/2937138

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-4-3
pubmed:abstractText
Dendritic cells were isolated from peripheral blood, synovial fluid, and synovial tissue of patients with rheumatoid arthritis and from peripheral blood of healthy blood donors on the basis of semiadherence to plastic surfaces. The cells were compared with autologous peripheral blood monocytes with respect to their stimulating capacities in allogeneic and autologous mixed leukocyte reactions (MLR). Dendritic cells from the various compartments stimulated allogeneic T cells 6-14 times more than monocytes did. Dendritic cells also stimulated autologous T cells 10-24 times more than monocytes did. Evidence in favour of the dendritic cell as the major stimulating cell type in MLR was also found in mixed experiments in which various ratios of dendritic cells and monocytes were used as stimulator cells. Furthermore, the activating structures on the dendritic cells seem to be major histocompatibility complex class II antigens, since anti-HLA-DR antibodies inhibited the responses. The results, especially from the autologous MLR, indicate that dendritic cells are important accessory cells for the various immune responses in rheumatoid inflammation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0300-9475
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
233-41
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Rheumatoid synovial dendritic cells as stimulators in allogeneic and autologous mixed leukocyte reactions--comparison with autologous monocytes as stimulator cells.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't