Linked Life Data

2921347

Source:http://linkedlifedata.com/resource/pubmed/id/2921347

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-4-20
pubmed:abstractText
Tolerance to penicillin was investigated in 40 isolates of optochin-resistant, alpha-haemolytic streptococci. Thirteen strains exhibited tolerance to penicillin (MBC:MIC ratio greater than or equal to 32) when stationary phase inocula were used, but only seven strains retained the tolerance phenotype in experiments with logarithmic phase inocula. There was a striking association between tolerance and Eagle's optimum dosage effect, particularly among strains that displayed tolerance in both the stationary and the logarithmic growth phases. Sequential viable counts on representative strains showed that reliance on the arbitrary criterion of bactericidal activity of 99.9% reduction of the original inoculum after 24 hours' exposure may occasionally lead to difficulties in the recognition of penicillin tolerance. In general, however, the 99.9% killing criterion provided a useful discriminator between strains that were rapidly killed by penicillin and those (tolerant strains) in which the bactericidal activity was much reduced.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-9746
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
77-80
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Tolerance to penicillin in streptococci of viridans group.
pubmed:affiliation
Department of Microbiology, University Hospital, Queen's Medical Centre, Nottingham.
pubmed:publicationType
Journal Article