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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1989-4-14
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pubmed:abstractText |
Extracts from a group of destagnative herbs, 764-1, and the effective chemical, 764-3, were tested by an in vitro experiment using a HeLa-S3 cell line. Under aerobic conditions, the shoulder of the cell survival curve diminished or disappeared according to the different doses of 764-1 used, but no change in slope was observed. In nitrogen, when the dose of 764-1 increased to 20 mg/ml (ID20), besides the disappearance of the shoulder, the slope of the curve also showed changes at lower doses (4-8 Gy); up to 10-25 Gy the curve became more flattened. 764-3 showed almost a similar effect by mainly affecting the shoulder of the survival curve. At low drug doses a SER as high as 1.87 might be obtained under hypoxic condition. At the same time 764-1 was used in testing the effect on radiation lung damage. It was found that 764-1 could markedly inhibit the change of alveolar surfactant at 1 and 3 weeks after radiation. A wide field of investigation is thus spread out in front of us on radiosensitization and protection. Further studies on 764-3 are carried out.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Drugs, Chinese Herbal,
http://linkedlifedata.com/resource/pubmed/chemical/Pulmonary Surfactants,
http://linkedlifedata.com/resource/pubmed/chemical/Radiation-Protective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Radiation-Sensitizing Agents
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0360-3016
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
16
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
347-52
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2921137-Animals,
pubmed-meshheading:2921137-Cell Survival,
pubmed-meshheading:2921137-Drugs, Chinese Herbal,
pubmed-meshheading:2921137-HeLa Cells,
pubmed-meshheading:2921137-Humans,
pubmed-meshheading:2921137-Lung,
pubmed-meshheading:2921137-Male,
pubmed-meshheading:2921137-Mice,
pubmed-meshheading:2921137-Pulmonary Surfactants,
pubmed-meshheading:2921137-Radiation-Protective Agents,
pubmed-meshheading:2921137-Radiation-Sensitizing Agents
|
pubmed:year |
1989
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pubmed:articleTitle |
The use of Chinese herb medicine in experimental radiotherapy.
|
pubmed:affiliation |
Dept. Radiation Oncology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing.
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|