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pubmed-article:2918683pubmed:abstractTextBacteremia with resultant damage to multiple organ systems remains a serious problem in intensive care of human patients. We have developed a clinically relevant swine model of sepsis-induced adult respiratory distress syndrome (ARDS). Twenty-three animals were given various doses of Pseudomonas aeruginosa intravenously. Low cardiac output septic shock was prevented with massive fluid infusion. It was found that a dose of 1.0 X 10(7) colony forming units per 20 kg/min for 2 hours reliably produced respiratory failure in a setting of hyperdynamic sepsis which meets the diagnostic criteria of human ARDS.lld:pubmed
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pubmed-article:2918683pubmed:pagination37-43lld:pubmed
pubmed-article:2918683pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:2918683pubmed:articleTitleCardiopulmonary responses to Pseudomonas septicemia in swine: an improved model of the adult respiratory distress syndrome.lld:pubmed
pubmed-article:2918683pubmed:affiliationDepartment of Surgery, Wellesley Hospital, Toronto, Ontario, Canada.lld:pubmed
pubmed-article:2918683pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2918683pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed