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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1989-4-4
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pubmed:abstractText |
Bacteremia with resultant damage to multiple organ systems remains a serious problem in intensive care of human patients. We have developed a clinically relevant swine model of sepsis-induced adult respiratory distress syndrome (ARDS). Twenty-three animals were given various doses of Pseudomonas aeruginosa intravenously. Low cardiac output septic shock was prevented with massive fluid infusion. It was found that a dose of 1.0 X 10(7) colony forming units per 20 kg/min for 2 hours reliably produced respiratory failure in a setting of hyperdynamic sepsis which meets the diagnostic criteria of human ARDS.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0023-6764
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
37-43
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2918683-Animals,
pubmed-meshheading:2918683-Blood Pressure,
pubmed-meshheading:2918683-Cardiac Output,
pubmed-meshheading:2918683-Disease Models, Animal,
pubmed-meshheading:2918683-Female,
pubmed-meshheading:2918683-Fluid Therapy,
pubmed-meshheading:2918683-Heart Rate,
pubmed-meshheading:2918683-Male,
pubmed-meshheading:2918683-Oxygen,
pubmed-meshheading:2918683-Pseudomonas Infections,
pubmed-meshheading:2918683-Respiratory Distress Syndrome, Adult,
pubmed-meshheading:2918683-Sepsis,
pubmed-meshheading:2918683-Shock, Septic,
pubmed-meshheading:2918683-Swine
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pubmed:year |
1989
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pubmed:articleTitle |
Cardiopulmonary responses to Pseudomonas septicemia in swine: an improved model of the adult respiratory distress syndrome.
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pubmed:affiliation |
Department of Surgery, Wellesley Hospital, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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