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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1989-2-9
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pubmed:abstractText |
C5-deficient mice grafted with thymus from C5-sufficient donors and immunized with C5 failed to make humoral antibody to C5, suggesting that the transfer of thymus had induced tolerance. Irradiated C5-deficient hosts repopulated with lymphoid cells from thymectomized C5-deficient mice grafted with C5-sufficient thymus also failed to respond to immunization with C5, thus showing that the state of tolerance can be adoptively transferred. These results demonstrate that natural tolerance to self-protein antigen is "learned" in the thymus.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2909657-14978855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2909657-2409209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2909657-2432148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2909657-2945729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2909657-3029267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2909657-315991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2909657-3486368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2909657-3494522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2909657-3553374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2909657-3616623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2909657-4164823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2909657-492335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2909657-5460795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2909657-6602338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2909657-6611506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2909657-6808076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2909657-6912276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2909657-6979047
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
169
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
285-90
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1989
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pubmed:articleTitle |
Role of the thymus in natural tolerance to an autologous protein antigen.
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pubmed:affiliation |
Division of Immunology, Children's Hospital, Boston, Massachusetts.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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