rdf:type |
|
lifeskim:mentions |
|
pubmed:dateCreated |
1990-1-4
|
pubmed:abstractText |
p185neu, the protein product of the neu gene, is a tyrosine kinase receptor with structural similarity to the epidermal growth factor (EGF) receptor. The cognate ligand for the p185neu receptor remains unknown. We have defined: 1) stage and tissue-specific expression patterns of the neu gene product in developing tissues; 2) p185neu phosphorylation and the regulation of p185neu tyrosine kinase activity by EGF. 3) Synergistic interactions of cellular rat p185neu and EGF receptor leading to cell transformation; 4) structural and functional differences of normal and oncogenic p185neu. These observations explain some features of how p185neu is involved in normal development and neoplastic transformation.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:author |
|
pubmed:volume |
19
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
45-57
|
pubmed:dateRevised |
2009-11-19
|
pubmed:meshHeading |
pubmed-meshheading:2908355-Animals,
pubmed-meshheading:2908355-Cell Transformation, Neoplastic,
pubmed-meshheading:2908355-Epidermal Growth Factor,
pubmed-meshheading:2908355-Gene Expression,
pubmed-meshheading:2908355-Phosphorylation,
pubmed-meshheading:2908355-Protein-Tyrosine Kinases,
pubmed-meshheading:2908355-Proto-Oncogene Proteins,
pubmed-meshheading:2908355-Proto-Oncogenes,
pubmed-meshheading:2908355-Rats,
pubmed-meshheading:2908355-Receptor, Epidermal Growth Factor,
pubmed-meshheading:2908355-Receptor, erbB-2
|
pubmed:year |
1988
|
pubmed:articleTitle |
The role of the neu oncogene product in cell transformation and normal development.
|
pubmed:affiliation |
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia 19104-6082.
|
pubmed:publicationType |
Journal Article,
Review
|