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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
8605
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pubmed:dateCreated |
1988-8-25
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pubmed:abstractText |
Halofantrine hydrochloride given to 46 Kenyan children with falciparum malaria at 10 mg/kg for two doses, and to 60 other children at 8 mg/kg for three doses, resulted in rapid parasite clearance, mean parasite clearance times being 45.4 h and 54.8 h, respectively. In-vitro chemosensitivity tests showed that most infections were due to chloroquine-resistant parasites, and that parasite maturation was inhibited by considerably lower concentrations of halofantrine than of chloroquine.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0140-6736
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
247-50
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pubmed:dateRevised |
2009-9-29
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pubmed:meshHeading |
pubmed-meshheading:2899237-Administration, Oral,
pubmed-meshheading:2899237-Adolescent,
pubmed-meshheading:2899237-Animals,
pubmed-meshheading:2899237-Antimalarials,
pubmed-meshheading:2899237-Child,
pubmed-meshheading:2899237-Child, Preschool,
pubmed-meshheading:2899237-Chloroquine,
pubmed-meshheading:2899237-Clinical Trials as Topic,
pubmed-meshheading:2899237-Drug Administration Schedule,
pubmed-meshheading:2899237-Drug Evaluation,
pubmed-meshheading:2899237-Drug Resistance,
pubmed-meshheading:2899237-Female,
pubmed-meshheading:2899237-Follow-Up Studies,
pubmed-meshheading:2899237-Half-Life,
pubmed-meshheading:2899237-Humans,
pubmed-meshheading:2899237-Infant,
pubmed-meshheading:2899237-Kenya,
pubmed-meshheading:2899237-Malaria,
pubmed-meshheading:2899237-Male,
pubmed-meshheading:2899237-Phenanthrenes,
pubmed-meshheading:2899237-Plasmodium falciparum,
pubmed-meshheading:2899237-Time Factors
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pubmed:year |
1988
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pubmed:articleTitle |
Efficacy of multiple-dose halofantrine in treatment of chloroquine-resistant falciparum malaria in children in Kenya.
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pubmed:affiliation |
Biomedical Sciences Research Centre, Kenya Medical Research Institute (KEMRI), Nairobi.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
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