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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1988-8-1
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pubmed:abstractText |
Immunity to infection with Eimeria vermiformis was transferred in NIH mice by both the nylon wool-adherent (B-cell-enriched) and nonadherent (T-cell-enriched) fractions of lymphocytes (spleen and mesenteric lymph node) taken from infected donors. Transfer was more variable with the adherent fraction, and when contaminating T cells were removed by treatment with anti-Thy1 monoclonal antibody (MAb) and complement, this fraction lost all protective activity. The protective effect of T-cell-enriched populations of mesenteric lymphocytes was abrogated by treatment with anti-L3T4 MAb and complement in vitro before transfer or by opsonization with this MAb in vitro before intravenous inoculation into recipients. Similar treatments of cells with anti-Lyt2 MAb did not have this effect, confirming that Thy1+ L3T4+ cells mediate the adoptive transfer of immunity to E. vermiformis. Thy1+ L3T4+ cells were also shown to limit the replication of E. vermiformis in primary infections: mice depleted of this subset (by thymectomy followed by intravenous injection of anti-L3T4 MAb) passed greater numbers of oocysts over a longer period of time than did mice similarly depleted of Lyt2+ cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-1010500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-2820868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-2953846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-311346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-316804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-317595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-3353129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-3486898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-3493338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-350761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-3579780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-3582572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-3774377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-3876979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-3876996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-3896835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-3989746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-4280162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-4587740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-4718863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-551377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-5578480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-6218215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-640741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-6425215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-6608083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-6709395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-6718052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-6983178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2898430-7099704
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1760-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2898430-Animals,
pubmed-meshheading:2898430-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:2898430-Antigens, Surface,
pubmed-meshheading:2898430-Antigens, Thy-1,
pubmed-meshheading:2898430-Coccidiosis,
pubmed-meshheading:2898430-Eimeria,
pubmed-meshheading:2898430-Female,
pubmed-meshheading:2898430-Immunization, Passive,
pubmed-meshheading:2898430-Lymph Nodes,
pubmed-meshheading:2898430-Lymphocyte Depletion,
pubmed-meshheading:2898430-Mice,
pubmed-meshheading:2898430-Mice, Inbred Strains,
pubmed-meshheading:2898430-Phenotype,
pubmed-meshheading:2898430-Spleen,
pubmed-meshheading:2898430-T-Lymphocytes,
pubmed-meshheading:2898430-Thymectomy
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pubmed:year |
1988
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pubmed:articleTitle |
Mediation of immunity to Eimeria vermiformis in mice by L3T4+ T cells.
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pubmed:affiliation |
Houghton Laboratory, Institute for Animal Health, Huntingdon, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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