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rdf:type |
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lifeskim:mentions |
umls-concept:C0018338,
umls-concept:C0018358,
umls-concept:C0031586,
umls-concept:C0033634,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0035647,
umls-concept:C0052644,
umls-concept:C0205160,
umls-concept:C0205409,
umls-concept:C0206686,
umls-concept:C0596901,
umls-concept:C0851285,
umls-concept:C1518174,
umls-concept:C1710082,
umls-concept:C1948027
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pubmed:issue |
1
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pubmed:dateCreated |
1988-3-7
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pubmed:abstractText |
Rat adrenocortical carcinoma cells possess a high density of atrial natriuretic factor (ANF) receptors which are coupled with membrane guanylate cyclase and corticosterone production. Herein we show that pretreatment of these cells with phorbol 12-myristate 13-acetate (PMA), a known activator of protein kinase C, attenuates the ANF-stimulated cyclic GMP accumulation in a dose-dependent manner. The half maximum inhibitory concentration of PMA was 10(-10) M. When these cells were incubated with PMA in the presence of 1-(5-isoquinolinyl-sulfonyl)-2-methyl piperazine, a protein kinase C inhibitor, the PMA-mediated attenuation of ANF-stimulated cyclic GMP formation is blocked. These results suggest that protein kinase C negatively regulates the ANF-receptor coupled membrane guanylate cyclase system in these cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-(5-Isoquinolinesulfonyl)-2-Methylp...,
http://linkedlifedata.com/resource/pubmed/chemical/Atrial Natriuretic Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Isoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Atrial Natriuretic Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/atrial natriuretic peptide, rat
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
227
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
47-50
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2892695-1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine,
pubmed-meshheading:2892695-Adrenal Cortex Neoplasms,
pubmed-meshheading:2892695-Animals,
pubmed-meshheading:2892695-Atrial Natriuretic Factor,
pubmed-meshheading:2892695-Cyclic GMP,
pubmed-meshheading:2892695-Enzyme Activation,
pubmed-meshheading:2892695-Guanylate Cyclase,
pubmed-meshheading:2892695-Isoquinolines,
pubmed-meshheading:2892695-Phosphorylation,
pubmed-meshheading:2892695-Piperazines,
pubmed-meshheading:2892695-Protein Kinase C,
pubmed-meshheading:2892695-Rats,
pubmed-meshheading:2892695-Receptors, Atrial Natriuretic Factor,
pubmed-meshheading:2892695-Receptors, Cell Surface,
pubmed-meshheading:2892695-Tetradecanoylphorbol Acetate
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pubmed:year |
1988
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pubmed:articleTitle |
Negative regulation of atrial natriuretic factor receptor coupled membrane guanylate cyclase by phorbol ester. Potential protein kinase C regulation of cyclic GMP signal in isolated adrenocortical carcinoma cells of rat.
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pubmed:affiliation |
Department of Biochemistry, University of Tennessee, Memphis 38163.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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