| pubmed-article:2891626 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2891626 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:2891626 | lifeskim:mentions | umls-concept:C0521457 | lld:lifeskim |
| pubmed-article:2891626 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:2891626 | lifeskim:mentions | umls-concept:C0596263 | lld:lifeskim |
| pubmed-article:2891626 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:2891626 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2891626 | lifeskim:mentions | umls-concept:C0442375 | lld:lifeskim |
| pubmed-article:2891626 | lifeskim:mentions | umls-concept:C1511545 | lld:lifeskim |
| pubmed-article:2891626 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2891626 | pubmed:dateCreated | 1988-1-25 | lld:pubmed |
| pubmed-article:2891626 | pubmed:abstractText | Mouse skin tumors were produced after transplacental initiation [with 7,12-dimethylbenz(a)anthracene], only when the skin was treated post-natally with a tumor-promoting agent (12-O-tetradecanoyl phorbol 13-acetate). DNA analysis of tumors showed that all carcinomas analyzed contained a specific mutation (A to T transversion) at the 61st codon of c-Ha-ras. Fifty per cent of the papillomas analyzed also had this same mutation. The A to T transversion at the 61st codon of Ha-ras was heterozygous in all positive papillomas and carcinomas. No such mutation was found when benzo(a)pyrene was used as an initiating agent. These results indicate that fetal c-Ha-ras can be transplacentally activated through a specific point mutation by a carcinogen, but a cell harboring such a mutation may remain dormant until it encounters a tumor-promoting stimulus. | lld:pubmed |
| pubmed-article:2891626 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2891626 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2891626 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2891626 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2891626 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2891626 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2891626 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2891626 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2891626 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2891626 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2891626 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2891626 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2891626 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:2891626 | pubmed:author | pubmed-author:YamasakiHH | lld:pubmed |
| pubmed-article:2891626 | pubmed:author | pubmed-author:MartelNN | lld:pubmed |
| pubmed-article:2891626 | pubmed:author | pubmed-author:TomatisLL | lld:pubmed |
| pubmed-article:2891626 | pubmed:author | pubmed-author:HollsteinMM | lld:pubmed |
| pubmed-article:2891626 | pubmed:author | pubmed-author:CabralJ RJR | lld:pubmed |
| pubmed-article:2891626 | pubmed:author | pubmed-author:GalendoDD | lld:pubmed |
| pubmed-article:2891626 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2891626 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2891626 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:2891626 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2891626 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2891626 | pubmed:pagination | 818-22 | lld:pubmed |
| pubmed-article:2891626 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2891626 | pubmed:meshHeading | pubmed-meshheading:2891626-... | lld:pubmed |
| pubmed-article:2891626 | pubmed:meshHeading | pubmed-meshheading:2891626-... | lld:pubmed |
| pubmed-article:2891626 | pubmed:meshHeading | pubmed-meshheading:2891626-... | lld:pubmed |
| pubmed-article:2891626 | pubmed:meshHeading | pubmed-meshheading:2891626-... | lld:pubmed |
| pubmed-article:2891626 | pubmed:meshHeading | pubmed-meshheading:2891626-... | lld:pubmed |
| pubmed-article:2891626 | pubmed:meshHeading | pubmed-meshheading:2891626-... | lld:pubmed |
| pubmed-article:2891626 | pubmed:meshHeading | pubmed-meshheading:2891626-... | lld:pubmed |
| pubmed-article:2891626 | pubmed:meshHeading | pubmed-meshheading:2891626-... | lld:pubmed |
| pubmed-article:2891626 | pubmed:meshHeading | pubmed-meshheading:2891626-... | lld:pubmed |
| pubmed-article:2891626 | pubmed:meshHeading | pubmed-meshheading:2891626-... | lld:pubmed |
| pubmed-article:2891626 | pubmed:meshHeading | pubmed-meshheading:2891626-... | lld:pubmed |
| pubmed-article:2891626 | pubmed:meshHeading | pubmed-meshheading:2891626-... | lld:pubmed |
| pubmed-article:2891626 | pubmed:meshHeading | pubmed-meshheading:2891626-... | lld:pubmed |
| pubmed-article:2891626 | pubmed:meshHeading | pubmed-meshheading:2891626-... | lld:pubmed |
| pubmed-article:2891626 | pubmed:meshHeading | pubmed-meshheading:2891626-... | lld:pubmed |
| pubmed-article:2891626 | pubmed:meshHeading | pubmed-meshheading:2891626-... | lld:pubmed |
| pubmed-article:2891626 | pubmed:meshHeading | pubmed-meshheading:2891626-... | lld:pubmed |
| pubmed-article:2891626 | pubmed:meshHeading | pubmed-meshheading:2891626-... | lld:pubmed |
| pubmed-article:2891626 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2891626 | pubmed:articleTitle | Transplacental induction of a specific mutation in fetal Ha-ras and its critical role in post-natal carcinogenesis. | lld:pubmed |
| pubmed-article:2891626 | pubmed:affiliation | International Agency for Research on Cancer, Lyon, France. | lld:pubmed |
| pubmed-article:2891626 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2891626 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2891626 | lld:pubmed |
