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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1988-1-25
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pubmed:abstractText |
Mouse skin tumors were produced after transplacental initiation [with 7,12-dimethylbenz(a)anthracene], only when the skin was treated post-natally with a tumor-promoting agent (12-O-tetradecanoyl phorbol 13-acetate). DNA analysis of tumors showed that all carcinomas analyzed contained a specific mutation (A to T transversion) at the 61st codon of c-Ha-ras. Fifty per cent of the papillomas analyzed also had this same mutation. The A to T transversion at the 61st codon of Ha-ras was heterozygous in all positive papillomas and carcinomas. No such mutation was found when benzo(a)pyrene was used as an initiating agent. These results indicate that fetal c-Ha-ras can be transplacentally activated through a specific point mutation by a carcinogen, but a cell harboring such a mutation may remain dormant until it encounters a tumor-promoting stimulus.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0020-7136
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
818-22
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2891626-9,10-Dimethyl-1,2-benzanthracene,
pubmed-meshheading:2891626-Animals,
pubmed-meshheading:2891626-Benzo(a)pyrene,
pubmed-meshheading:2891626-Carcinoma,
pubmed-meshheading:2891626-Cocarcinogenesis,
pubmed-meshheading:2891626-DNA, Neoplasm,
pubmed-meshheading:2891626-Female,
pubmed-meshheading:2891626-Mice,
pubmed-meshheading:2891626-Mutation,
pubmed-meshheading:2891626-Papilloma,
pubmed-meshheading:2891626-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:2891626-Pregnancy,
pubmed-meshheading:2891626-Prenatal Exposure Delayed Effects,
pubmed-meshheading:2891626-Proto-Oncogene Proteins,
pubmed-meshheading:2891626-Proto-Oncogene Proteins p21(ras),
pubmed-meshheading:2891626-Proto-Oncogenes,
pubmed-meshheading:2891626-Skin Neoplasms,
pubmed-meshheading:2891626-Tetradecanoylphorbol Acetate
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pubmed:year |
1987
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pubmed:articleTitle |
Transplacental induction of a specific mutation in fetal Ha-ras and its critical role in post-natal carcinogenesis.
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pubmed:affiliation |
International Agency for Research on Cancer, Lyon, France.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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