| pubmed-article:2886766 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2886766 | lifeskim:mentions | umls-concept:C0001699 | lld:lifeskim |
| pubmed-article:2886766 | lifeskim:mentions | umls-concept:C0012652 | lld:lifeskim |
| pubmed-article:2886766 | lifeskim:mentions | umls-concept:C0007732 | lld:lifeskim |
| pubmed-article:2886766 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:2886766 | pubmed:issue | 8554 | lld:pubmed |
| pubmed-article:2886766 | pubmed:dateCreated | 1987-9-14 | lld:pubmed |
| pubmed-article:2886766 | pubmed:abstractText | Klebsiella pneumoniae strains that were resistant to third-generation cephalosporins and amikacin were recovered from 62 of 395 patients (15.7%) during 1986. 25 isolates (40%) caused urinary tract infections. The outbreak involved three intensive care units (54 isolates), and spread from one unit to another and then to four wards (8 isolates). K pneumoniae of various serotypes and strains of different Enterobacteriaceae demonstrating the same antibiotic resistance pattern were isolated, which suggests dissemination of an R-factor. The isolates had low-level resistance to third-generation cephalosporins (mode minimum inhibitory concentration of cefotaxime, 2 mg/l) but remained sensitive to cephamycins. Cefotaxime was effective in cases of uncomplicated urinary tract infection, but failed in major infections at other sites. 1-5 mg/l of the beta-lactamase inhibitors clavulanic acid or sulbactam restored normal activity to cefotaxime against the multiresistant strains. Resistance to third-generation cephalosporins was mediated by a new broad-spectrum enzyme of isoelectric point 6.3. Resistance to beta-lactams and aminoglycosides was transferable to Escherichia coli. The emergence of transferable enzymatic resistance to newer beta-lactams in K pneumoniae strains indicates a major risk of spread of such resistance to otherwise sensitive strains. | lld:pubmed |
| pubmed-article:2886766 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2886766 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2886766 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2886766 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2886766 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2886766 | pubmed:issn | 0140-6736 | lld:pubmed |
| pubmed-article:2886766 | pubmed:author | pubmed-author:LegrandPP | lld:pubmed |
| pubmed-article:2886766 | pubmed:author | pubmed-author:DuvalJJ | lld:pubmed |
| pubmed-article:2886766 | pubmed:author | pubmed-author:PhilipponAA | lld:pubmed |
| pubmed-article:2886766 | pubmed:author | pubmed-author:Brun-BuissonC... | lld:pubmed |
| pubmed-article:2886766 | pubmed:author | pubmed-author:AnsquerMM | lld:pubmed |
| pubmed-article:2886766 | pubmed:author | pubmed-author:MontraversFF | lld:pubmed |
| pubmed-article:2886766 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2886766 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:2886766 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:2886766 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2886766 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2886766 | pubmed:pagination | 302-6 | lld:pubmed |
| pubmed-article:2886766 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:2886766 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:2886766 | pubmed:articleTitle | Transferable enzymatic resistance to third-generation cephalosporins during nosocomial outbreak of multiresistant Klebsiella pneumoniae. | lld:pubmed |
| pubmed-article:2886766 | pubmed:publicationType | Journal Article | lld:pubmed |
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