Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8554
|
| pubmed:dateCreated |
1987-9-14
|
| pubmed:abstractText |
Klebsiella pneumoniae strains that were resistant to third-generation cephalosporins and amikacin were recovered from 62 of 395 patients (15.7%) during 1986. 25 isolates (40%) caused urinary tract infections. The outbreak involved three intensive care units (54 isolates), and spread from one unit to another and then to four wards (8 isolates). K pneumoniae of various serotypes and strains of different Enterobacteriaceae demonstrating the same antibiotic resistance pattern were isolated, which suggests dissemination of an R-factor. The isolates had low-level resistance to third-generation cephalosporins (mode minimum inhibitory concentration of cefotaxime, 2 mg/l) but remained sensitive to cephamycins. Cefotaxime was effective in cases of uncomplicated urinary tract infection, but failed in major infections at other sites. 1-5 mg/l of the beta-lactamase inhibitors clavulanic acid or sulbactam restored normal activity to cefotaxime against the multiresistant strains. Resistance to third-generation cephalosporins was mediated by a new broad-spectrum enzyme of isoelectric point 6.3. Resistance to beta-lactams and aminoglycosides was transferable to Escherichia coli. The emergence of transferable enzymatic resistance to newer beta-lactams in K pneumoniae strains indicates a major risk of spread of such resistance to otherwise sensitive strains.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0140-6736
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
8
|
| pubmed:volume |
2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
302-6
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2886766-Amikacin,
pubmed-meshheading:2886766-Cefotaxime,
pubmed-meshheading:2886766-Cephalosporins,
pubmed-meshheading:2886766-Cross Infection,
pubmed-meshheading:2886766-Disease Outbreaks,
pubmed-meshheading:2886766-Drug Resistance, Microbial,
pubmed-meshheading:2886766-Enterobacteriaceae,
pubmed-meshheading:2886766-Escherichia coli,
pubmed-meshheading:2886766-Humans,
pubmed-meshheading:2886766-Klebsiella Infections,
pubmed-meshheading:2886766-Klebsiella pneumoniae,
pubmed-meshheading:2886766-Paris,
pubmed-meshheading:2886766-Recurrence,
pubmed-meshheading:2886766-Urinary Tract Infections,
pubmed-meshheading:2886766-beta-Lactamases
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Transferable enzymatic resistance to third-generation cephalosporins during nosocomial outbreak of multiresistant Klebsiella pneumoniae.
|
| pubmed:publicationType |
Journal Article
|