Linked Life Data

2873786

Source:http://linkedlifedata.com/resource/pubmed/id/2873786

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1986-8-14
pubmed:abstractText
The efficacy of intravenous and enteral administration of rifampicin was studied comparatively in treatment of hematogenic diseminated tuberculosis in rabbits. The drugs were administered in a dose of 10 mg/kg for 60 days. The functional state of the liver was studied in the time course by activity of urokinase, a hepatospecific enzyme and transaminases. Monotherapy with rifampicin capsules administered enterally resulted in death of 66.6 per cent of the animals due to tuberculosis during the first month of the treatment. Completion of the treatment course in 4 rabbits did not result in abacillation. When rifampicin was administered intravenously no deaths of the animals due to tuberculosis were recorded. Complete abacillation of the internal organs was observed in 37.5 per cent of the rabbits. The changes in activity of the indicator enzymes were transient and after discontinuation of the treatment came to normal.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0233-7525
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
378-81
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
[Comparative effectiveness of the enteral and intravenous administration of rifampicin in treating experimental tuberculosis in rabbits].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract