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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6056
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pubmed:dateCreated |
1986-4-10
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pubmed:databankReference |
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pubmed:abstractText |
A biologically active complementary DNA clone of a transforming gene present in a human colon carcinoma contains gene sequences of both tropomyosin and a previously unknown protein tyrosine kinase. The predicted protein (641 amino acids) encoded by this oncogene seems to have been formed by a somatic rearrangement that replaced the extracellular domain of a putative transmembrane receptor by the first 221 amino acids of a non-muscle tropomyosin molecule.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
319
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
743-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2869410-Amino Acid Sequence,
pubmed-meshheading:2869410-Base Sequence,
pubmed-meshheading:2869410-Cell Transformation, Neoplastic,
pubmed-meshheading:2869410-Cloning, Molecular,
pubmed-meshheading:2869410-DNA,
pubmed-meshheading:2869410-Humans,
pubmed-meshheading:2869410-Oncogenes,
pubmed-meshheading:2869410-Poly A,
pubmed-meshheading:2869410-Protein-Tyrosine Kinases,
pubmed-meshheading:2869410-RNA, Messenger,
pubmed-meshheading:2869410-Tropomyosin
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pubmed:articleTitle |
A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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