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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1985-12-20
|
| pubmed:abstractText |
Subtotal destruction of central noradrenergic neurons with the neurotoxin, 6-hydroxydopamine, is known to increase tyrosine hydroxylase (TH) activity within surviving nerve terminals. The present report demonstrates a similar, dose-related elevation of TH activity in the adrenal medulla and sympathetic nerves after systemic 6-hydroxydopamine treatment. Two temporally distinct processes were observed in the sympathetic nerves: a rapid activation of TH, present during the first few days after the lesion, and a more gradual increase in maximal TH activity, most probably due to enzyme induction. In this regard, the stimulatory effect on catecholamine biosynthesis of cyclic AMP-dependent phosphorylation was attenuated substantially within cardiac sympathetic nerves 3 days after the lesion, but by 3 weeks the efficacy of cyclic AMP-dependent phosphorylation was restored completely. Similarly, the normal activation of cardiac TH activity elicited by insulin-induced hypoglycemia and cold stress was absent soon after 6-hydroxydopamine treatment, but returned 3 weeks later. These latter findings suggest that the adaptations within the sympathoadrenal system after subtotal sympathectomy can preclude further adaptations to stress.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxydopamines,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidopamine,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine 3-Monooxygenase
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0022-3565
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
235
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
354-60
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:2865349-Adrenal Medulla,
pubmed-meshheading:2865349-Animals,
pubmed-meshheading:2865349-Cold Temperature,
pubmed-meshheading:2865349-Dose-Response Relationship, Drug,
pubmed-meshheading:2865349-Enzyme Activation,
pubmed-meshheading:2865349-Heart,
pubmed-meshheading:2865349-Hydroxydopamines,
pubmed-meshheading:2865349-Male,
pubmed-meshheading:2865349-Myocardium,
pubmed-meshheading:2865349-Norepinephrine,
pubmed-meshheading:2865349-Oxidopamine,
pubmed-meshheading:2865349-Phosphorylation,
pubmed-meshheading:2865349-Protein Kinases,
pubmed-meshheading:2865349-Rats,
pubmed-meshheading:2865349-Rats, Inbred Strains,
pubmed-meshheading:2865349-Stress, Physiological,
pubmed-meshheading:2865349-Sympathectomy, Chemical,
pubmed-meshheading:2865349-Sympathetic Nervous System,
pubmed-meshheading:2865349-Tyrosine 3-Monooxygenase
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Tyrosine hydroxylase activity in the sympathoadrenal system under basal and stressful conditions: effect of 6-hydroxydopamine.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|