Linked Life Data

2859370

Source:http://linkedlifedata.com/resource/pubmed/id/2859370

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1985-6-3
pubmed:abstractText
The N-2 atoms of phosphorus 2,2-dimethylhydrazides, contrary to a previous report, can be methylated by iodomethane. Treatment of the resulting dihydrazinium iodides with aqueous sodium hydroxide results in mono- instead of didehydroiodination, apparently due to resonance stabilization of the inner salt form. The phosphaminimide products and their hydrazinium iodide precursors blocked sympathetic ganglionic transmission while one dihydrazide intermediate produced potentiation. Brine shrimp testing indicated that conversion of a hydrazinium iodide to an aminimide moiety results in decreased toxicity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
595-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Phosphorus-nitrogen compounds. 26. Phosphaminimides. 2. 2,2'-Phosphinylidenebis(1,1,1-trimethylhydrazinium) iodide inner salts as agents affecting ganglionic transmission.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't