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rdf:type |
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lifeskim:mentions |
umls-concept:C0005456,
umls-concept:C0034493,
umls-concept:C0053104,
umls-concept:C0127400,
umls-concept:C0237753,
umls-concept:C0348016,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2004454,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
1985-6-19
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pubmed:abstractText |
The densities of [3H]-prazosin and [3H]-clonidine binding sites were determined in spleen and brain membrane preparations from rabbits treated 1 to 48 h previously with benextramine (5 mg/kg). In other rabbits pressor responses to phenylephrine and BHT 920 were examined 1 to 72 h after benextramine administration. After benextramine there was a reduction in the density of both [3H] prazosin and [3H] clonidine binding sites in spleen and a non-parallel shift in pressor dose response curves to selective alpha 1- and alpha 2-adrenoreceptor agonists. Recovery of in vivo responses and binding site densities were relatively slow. No reduction in the maximum density of either [3H] prazosin or [3H] clonidine binding sites in brain was found after intravenous administration of benextramine. It is concluded that after intravenous administration benextramine binds irreversibly to peripheral alpha 1- and alpha 2-adrenoreceptors in the rabbit but fails to cross the blood brain barrier in appreciable quantities and bind to central alpha-adrenoreceptors. Recovery of in vivo responses was more rapid than that previously observed after alpha-adrenoreceptor blockade with phenoxybenzamine. The longer time course of recovery after phenoxybenzamine may be a result of redistribution of this lipophilic drug from fat.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Azepines,
http://linkedlifedata.com/resource/pubmed/chemical/Clonidine,
http://linkedlifedata.com/resource/pubmed/chemical/Cystamine,
http://linkedlifedata.com/resource/pubmed/chemical/Phenoxybenzamine,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Prazosin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha,
http://linkedlifedata.com/resource/pubmed/chemical/benextramine,
http://linkedlifedata.com/resource/pubmed/chemical/talipexole
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0144-1795
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13-7
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:2859290-Adrenergic alpha-Agonists,
pubmed-meshheading:2859290-Adrenergic alpha-Antagonists,
pubmed-meshheading:2859290-Animals,
pubmed-meshheading:2859290-Azepines,
pubmed-meshheading:2859290-Blood Pressure,
pubmed-meshheading:2859290-Brain,
pubmed-meshheading:2859290-Clonidine,
pubmed-meshheading:2859290-Cystamine,
pubmed-meshheading:2859290-Injections, Intravenous,
pubmed-meshheading:2859290-Male,
pubmed-meshheading:2859290-Membranes,
pubmed-meshheading:2859290-Phenoxybenzamine,
pubmed-meshheading:2859290-Phenylephrine,
pubmed-meshheading:2859290-Prazosin,
pubmed-meshheading:2859290-Rabbits,
pubmed-meshheading:2859290-Receptors, Adrenergic, alpha,
pubmed-meshheading:2859290-Spleen,
pubmed-meshheading:2859290-Time Factors
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pubmed:year |
1985
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pubmed:articleTitle |
Recovery of alpha-adrenoreceptor mediated responses and binding site number after intravenous benextramine in the rabbit.
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pubmed:publicationType |
Journal Article
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