Linked Life Data

2858256

Source:http://linkedlifedata.com/resource/pubmed/id/2858256

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1985-5-23
pubmed:abstractText
The distribution of somatostatin-like immunoreactivity in the caudate, putamen, globus pallidus and ventral mesencephalon of the normal human brain has been studied with immunocytochemical techniques, and compared to that seen in Huntington's disease. Within the normal striatum, sparsely distributed varicose fibers and a population of medium-sized neurons were stained. In Huntington's disease, somatostatin immunoreactive striatal neurons appear to degenerate in proportion to the loss of striatal tissue, but there is an increase in the density of immunostained varicose fibers. In contrast, the pattern and amount of fiber staining in the substantia nigra appeared virtually unchanged from that seen in the normal brain. The morphology of striatal perikarya containing somatostatin-like immunoreactivity and the patterns of fiber staining in normal and Huntington's disease pallidum and substantia nigra suggest that striatal neurons containing somatostatin-like immunoreactivity are local circuit neurons.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
329
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71-82
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Huntington's disease is accompanied by changes in the distribution of somatostatin-containing neuronal processes.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.