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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1993-8-31
|
| pubmed:abstractText |
The influence of nifedipine treatment on plasma (PV) and extracellular fluid volume (ECV), the ratio of plasma volume to interstitial fluid volume (PV:IF), glomerular filtration rate (GFR), renal clearances of Na+ and K+, plasma concentrations of renin (PRC), angiotensin II (pANG II), aldosterone (pAldo), adrenaline (PA) and noradrenaline (PNA) were studied in 18 consecutive patients with essential hypertension. A 4-week placebo period was followed by a 6-week dose-titration period (period A). Thereafter the dose was kept constant for an additional 6 weeks (period B), the mean dose being 51 mg/day. As compared with placebo, diastolic blood pressure (DBP) decreased from 105 +/- 7 to 93 +/- 9 mmHg at the end of period B. Extracellular fluid volume, PV, and PV:IF were not significantly changed at the end of period A or B, neither in the group as a whole nor in a subgroup, who developed pedal oedema. After 2 weeks on nifedipine, PA as well as PNA increased slightly but returned to control values after 6 weeks of therapy. Plasma renin concentration, pANG II, pAldo and GFR did not change significantly. Renal sodium handling was also unchanged. It is concluded that long-term nifedipine therapy (exceeding 6 weeks) does not lead to activation of counter-regulatory mechanisms such as fluid retention, activation of the renin-angiotensin system and the adrenergic system. Renal function is unaffected by nifedipine.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0952-1178
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
S223-5
|
| pubmed:dateRevised |
2005-6-8
|
| pubmed:meshHeading |
pubmed-meshheading:2856709-Adult,
pubmed-meshheading:2856709-Aged,
pubmed-meshheading:2856709-Body Fluid Compartments,
pubmed-meshheading:2856709-Female,
pubmed-meshheading:2856709-Humans,
pubmed-meshheading:2856709-Hypertension,
pubmed-meshheading:2856709-Male,
pubmed-meshheading:2856709-Middle Aged,
pubmed-meshheading:2856709-Nifedipine,
pubmed-meshheading:2856709-Renin-Angiotensin System
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
The influence of nifedipine treatment on counter-regulatory mechanisms in essential hypertension.
|
| pubmed:affiliation |
Medical Department C, Glostrup Hospital, Denmark.
|
| pubmed:publicationType |
Journal Article
|