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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1989-8-11
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pubmed:abstractText |
1. Whole-cell recordings of voltage-gated Ca2+ current in single smooth muscle cells from rabbit ear artery were obtained with 110 mM-Ba2+ as charge carrier. 2. Noradrenaline (NA, 1-20 microM) produced a sustained increase in the dihydropyridine-sensitive L-type Ca2+ current, ranging up to 3-fold in some cells. The dihydropyridine-resistant T-type Ca2+ current was not affected. 3. The time and voltage dependence of activation and inactivation of the L-type current were not significantly changed during NA modulation. 4. The NA-induced increase in L-current was enhanced in magnitude and consistency by the inclusion of 200 microM-GTP in the pipette (internal) solution. 5. The effect of NA on L-current was not abolished by pre-treatment with prazosin, phentolamine or propranolol, suggesting that it is not mediated by alpha- or beta-adrenoceptors. 6. Phenylephrine (5 microM) was ineffective as an agonist, while adrenaline was approximately equipotent to NA. In these respects, the pharmacology of L-current modulation resembles that of 'gamma'-adrenergic receptors (Hirst & Nield, 1980). 7. NA modulation of L-type Ca2+ channels may be particularly important in promoting sympathetic vasoconstriction in resistance vessels where Ca2+ stores are relatively poorly developed and where NA-evoked contractions are very sensitive to organic Ca2+ channel antagonists.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-13588568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-224400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-2409600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-2411846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-2417192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-2425878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-2427250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-2431318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-2434867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-2439921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-2441356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-2442353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-2442626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-2448744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-2451016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-2869546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-3013455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-3033708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-37533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-3827881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-4296170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-6110212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-6110462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-6127405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-6131381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-6199538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-6243746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-6246131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-6270629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-6689958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2855354-894254
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,4-dihydropyridine,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Dihydropyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-3751
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
404
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
767-84
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2855354-Animals,
pubmed-meshheading:2855354-Calcium Channel Agonists,
pubmed-meshheading:2855354-Calcium Channel Blockers,
pubmed-meshheading:2855354-Calcium Channels,
pubmed-meshheading:2855354-Dihydropyridines,
pubmed-meshheading:2855354-Dose-Response Relationship, Drug,
pubmed-meshheading:2855354-Evoked Potentials,
pubmed-meshheading:2855354-Guanosine Triphosphate,
pubmed-meshheading:2855354-Muscle, Smooth, Vascular,
pubmed-meshheading:2855354-Muscle Contraction,
pubmed-meshheading:2855354-Norepinephrine,
pubmed-meshheading:2855354-Phenylephrine,
pubmed-meshheading:2855354-Rabbits,
pubmed-meshheading:2855354-Receptors, Adrenergic
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pubmed:year |
1988
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pubmed:articleTitle |
Noradrenaline modulation of calcium channels in single smooth muscle cells from rabbit ear artery.
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pubmed:affiliation |
Department of Physiology, Yale University School of Medicine, New Haven, CT 06510.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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