Linked Life Data

2855029

Source:http://linkedlifedata.com/resource/pubmed/id/2855029

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1989-7-25
pubmed:abstractText
1. Voltage-sensitive sodium and calcium channels play critical roles in the electrical excitability of nerve and muscle cells. These ion channels have been purified in functional form, their protein components have been characterized, and the role of their subunits in ion channel function has been studied. Each ion channel has a principal high molecular weight subunit which contains the main functional domains in association with additional smaller subunits whose functional roles are not yet established. Both channels are substrates for cAMP-dependent protein phosphorylation. The expression of the protein components of these channels is tissue-specific. 2. Analyses of the primary structure of the principal alpha subunit of the sodium channel have led to specific hypotheses for the structural basis of formation of a transmembrane ion channel and for voltage-dependent gating.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0100-879X
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1129-44
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Molecular properties of voltage-sensitive sodium and calcium channels.
pubmed:affiliation
Department of Pharmacology, University of Washington, Seattle 98195.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Review