Linked Life Data

2854003

Source:http://linkedlifedata.com/resource/pubmed/id/2854003

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-6-1
pubmed:abstractText
In cells transformed in vitro by different agents we have identified two discrete characteristics essential for in vivo selection by the effectors of host natural resistance. These two biochemically distinct characteristics, ie resistance to hydrogen peroxide and ability to secrete E type prostaglandin (PGE) in contact with NK cells, macrophages and neutrophils, may both be expressed either in about 100% of cells transformed by Rous sarcoma virus, or in less than 0.1% of cells transformed spontaneously. The expression of these characteristics provides the cells with selective advantages in vivo and determines the level of their tumorigenic activity and experimental metastasis-forming activity. These characteristics are apparently necessary, but insufficient, for spontaneous metastasizing activity. Demonstrated NK resistance of malignant cell variants is directly connected with their ability to produce PGE. The in vitro transformed cells which do not possess these qualities apparently have no ability for in vivo survival and growth. Though these two cellular properties are connected with biochemically different pathways (catabolism of H2O2 and metabolism of arachidonic acid) they are jointly expressed, or not expressed, in transformed cells. The possible mechanisms of in vivo selection of malignant cell variants, with one or a few cell properties united in clusters, and the dual role of natural resistance in this process are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0261-2429
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
675-90
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Natural host resistance and in vivo selection of malignant tumour cells.
pubmed:affiliation
Institute of Carcinogenesis, Academy of Medical Sciences, Moscow, USSR.
pubmed:publicationType
Journal Article, Review