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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1989-1-24
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pubmed:abstractText |
Theiler's virus is a picornavirus responsible for a persistent, demyelinating infection of mouse central nervous system. We examined the nature of infected cells during the course of this disease using a simultaneous immunoperoxidase-in situ hybridization assay. Cell types were identified with antigenic markers and infected cells were recognized by the presence of viral RNA. We found that, depending on the animal, approximately 10% of infected cells were migroglia-macrophages, 5 to 10% were astrocytes and 25 to 40% were oligodendrocytes. Approximately half of the infected cells could not be identified.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0882-4010
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
319-26
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2849023-Animals,
pubmed-meshheading:2849023-Astrocytes,
pubmed-meshheading:2849023-Carbonic Anhydrases,
pubmed-meshheading:2849023-Demyelinating Diseases,
pubmed-meshheading:2849023-Enterovirus,
pubmed-meshheading:2849023-Enterovirus Infections,
pubmed-meshheading:2849023-Glial Fibrillary Acidic Protein,
pubmed-meshheading:2849023-Immunoenzyme Techniques,
pubmed-meshheading:2849023-Immunohistochemistry,
pubmed-meshheading:2849023-Macrophages,
pubmed-meshheading:2849023-Maus Elberfeld virus,
pubmed-meshheading:2849023-Mice,
pubmed-meshheading:2849023-Nucleic Acid Hybridization,
pubmed-meshheading:2849023-Oligodendroglia,
pubmed-meshheading:2849023-RNA, Viral,
pubmed-meshheading:2849023-Spinal Cord
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pubmed:year |
1987
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pubmed:articleTitle |
Identification of Theiler's virus infected cells in the central nervous system of the mouse during demyelinating disease.
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pubmed:affiliation |
Départment de Virologie, UA CNRS 041157, Institut Pasteur, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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