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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1989-1-25
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pubmed:abstractText |
The effect of anticonvulsants on pentylenetetrazol (PTZ)-induced EEG power spectrum changes was examined. When the minimum dose of PTZ (15 mg/kg) was administered intravenously twice, with an interval of 80 min, a clear EEG power spectrum change was observed after the second PTZ administration, irrespective of whether or not the first PTZ administration evoked marked EEG changes. We defined the values F/N, S/N and S/F. The value F/N, obtained by dividing the power spectrum area after the first PTZ administration by the normal power spectrum area, was 1.06 +/- 0.05 (mean +/- S.E.). The value S/N, obtained by dividing the power spectrum area after the second PTZ administration by the normal power spectrum area, was 2.00 +/- 0.21. The value S/F, obtained by dividing S/N by F/N, was 1.86 +/- 0.16. The S/F value was almost constant regardless of whether or not the first PTZ administration could evoke marked EEG changes. The effect of anticonvulsants was examined by S/F value changes, and 100 mg/kg of PHT completely inhibited the double PTZ effect. Phenobarbital, ethosuximide and sodium valproate also inhibited the double PTZ effect. Using the S/F value of the EEG power spectrum with minimum dose double PTZ administration, quantitative evaluation is possible for anticonvulsant drugs.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anticonvulsants,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Ethosuximide,
http://linkedlifedata.com/resource/pubmed/chemical/Pentylenetetrazole,
http://linkedlifedata.com/resource/pubmed/chemical/Phenobarbital,
http://linkedlifedata.com/resource/pubmed/chemical/Valproic Acid
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0920-1211
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
265-71
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:2848695-Animals,
pubmed-meshheading:2848695-Anticonvulsants,
pubmed-meshheading:2848695-Cerebral Cortex,
pubmed-meshheading:2848695-Cyclic AMP,
pubmed-meshheading:2848695-Electroencephalography,
pubmed-meshheading:2848695-Ethosuximide,
pubmed-meshheading:2848695-Male,
pubmed-meshheading:2848695-Pentylenetetrazole,
pubmed-meshheading:2848695-Phenobarbital,
pubmed-meshheading:2848695-Rats,
pubmed-meshheading:2848695-Rats, Inbred Strains,
pubmed-meshheading:2848695-Seizures,
pubmed-meshheading:2848695-Valproic Acid
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pubmed:year |
1987
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pubmed:articleTitle |
Effect of anticonvulsants on pentylenetetrazol-induced power spectrum changes in electroencephalograms in rats.
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pubmed:affiliation |
Department of Physiology, Kanagawa Dental College, Yokosuka, Japan.
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pubmed:publicationType |
Journal Article
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