Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1988-12-22
pubmed:abstractText
The mode of action of a new type of UDP-glucose analog against herpes simplex virus type 1 (HSV-1) replication was examined. The analog showed good selectivity and potent activity. At 10 micrograms/ml, P-536 inhibited the formation of infectious HSV-1 by more than 90%, whereas at 100 micrograms/ml it had no cytotoxic effects, as evidenced by phase-contrast microscopy. P-536 showed a wide spectrum of action and was active against HSV-1, adenovirus type 5, vaccinia virus, poliovirus type 1, encephalomyocarditis virus, vesicular stomatitis virus, influenza virus, and measles virus, irrespective of whether these viruses have lipidic envelopes or not. P-536 clearly inhibited protein glycosylation if added at the time when late viral proteins were being synthesized. Moreover, it also interfered with the synthesis of nucleic acids and the phosphorylation of nucleosides. If P-536 was present from the beginning of infection, HSV-1 replication was blocked at an early step and the infected cells continued to synthesize cellular proteins for long periods.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2847650-2981323, http://linkedlifedata.com/resource/pubmed/commentcorrection/2847650-2997997, http://linkedlifedata.com/resource/pubmed/commentcorrection/2847650-2998063, http://linkedlifedata.com/resource/pubmed/commentcorrection/2847650-6154876, http://linkedlifedata.com/resource/pubmed/commentcorrection/2847650-6181775, http://linkedlifedata.com/resource/pubmed/commentcorrection/2847650-6184015, http://linkedlifedata.com/resource/pubmed/commentcorrection/2847650-6194404, http://linkedlifedata.com/resource/pubmed/commentcorrection/2847650-6208444, http://linkedlifedata.com/resource/pubmed/commentcorrection/2847650-6286786, http://linkedlifedata.com/resource/pubmed/commentcorrection/2847650-6293188, http://linkedlifedata.com/resource/pubmed/commentcorrection/2847650-6296282, http://linkedlifedata.com/resource/pubmed/commentcorrection/2847650-6301148, http://linkedlifedata.com/resource/pubmed/commentcorrection/2847650-6517562
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1257-61
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Mode of action of a new type of UDP-glucose analog against herpesvirus replication.
pubmed:affiliation
Departamento de Microbiología, Universidad Autónoma de Madrid, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't