rdf:type |
|
lifeskim:mentions |
umls-concept:C0018787,
umls-concept:C0030685,
umls-concept:C0036226,
umls-concept:C0205474,
umls-concept:C0391871,
umls-concept:C0439799,
umls-concept:C0521324,
umls-concept:C0596235,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1880022,
umls-concept:C1963578
|
pubmed:issue |
1-2
|
pubmed:dateCreated |
1988-12-12
|
pubmed:abstractText |
Rapid mixing-vesicle ion flux and planar lipid bilayer-single channel measurements have shown that a high-conductance, ligand-gated Ca2+ release channel is present in 'heavy', junctional-derived membrane fractions of skeletal and cardiac muscle sarcoplasmic reticulum. Using the release channel-specific probe, ryanodine, a 30S protein complex composed of polypeptides of Mr approximately 400,000 has been isolated from cardiac and skeletal muscle. Reconstitution of the complex into planar lipid bilayers has revealed a Ca2+ conductance with properties characteristic of the native Ca2+ release channel.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0300-8177
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
82
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
59-65
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:2847014-Adenine Nucleotides,
pubmed-meshheading:2847014-Animals,
pubmed-meshheading:2847014-Caffeine,
pubmed-meshheading:2847014-Calcium,
pubmed-meshheading:2847014-Calcium Channels,
pubmed-meshheading:2847014-Calmodulin,
pubmed-meshheading:2847014-Magnesium,
pubmed-meshheading:2847014-Muscles,
pubmed-meshheading:2847014-Myocardium,
pubmed-meshheading:2847014-Ryanodine,
pubmed-meshheading:2847014-Sarcoplasmic Reticulum
|
pubmed:articleTitle |
Biochemical characterization of the Ca2+ release channel of skeletal and cardiac sarcoplasmic reticulum.
|
pubmed:affiliation |
Department of Biochemistry, University of North Carolina, Chapel Hill 27599.
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|